BRD-K98645985

BRD-K98645985 is a BAF transcriptional repression inhibitor (EC50: ~2.37 μM). It binds ARID1A-specific BAF complexes, potently reverses HIV-1 latency and prevents nucleosomal positioning.

Catalog No. T10605Cas No. 1357647-78-9

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BRD-K98645985

Catalog No. T10605Cas No. 1357647-78-9

BRD-K98645985 is a BAF transcriptional repression inhibitor (EC50: ~2.37 μM). It binds ARID1A-specific BAF complexes, potently reverses HIV-1 latency and prevents nucleosomal positioning.

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Pack Size	Price	Availability
25 mg	$3,470	10-14 weeks
50 mg	$4,580	10-14 weeks
100 mg	$6,400	10-14 weeks

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Product Introduction

Bioactivity

Description	BRD-K98645985 is a BAF transcriptional repression inhibitor (EC50: ~2.37 µM). It binds ARID1A-specific BAF complexes, potently reverses HIV-1 latency and prevents nucleosomal positioning.
Targets&IC50	BAF transcriptional repression:2.37 μM （EC50）
In vitro	In J-Lat T-cell line models, BRD-K98645985 treatment shows a concentration-dependent latency reversal. BRD-K98645985 can be combined with other LRAs to improve reservoir targeting. BRD-K98645985 (30 μM; 18 hours) treatment shows a 5-fold increase in Bmi1, a 2.6-fold increase in Ring1, and a 3.3-fold decrease in Fgf4.

Chemical Properties

Molecular Weight	573.73
Formula	C₃₃H₄₃N₅O₄
Cas No.	1357647-78-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Keywords

BRD K98645985BRDK98645985BRD-K-98645985BRD-K 98645985BRD-K98645985