Boc-NH-PEG2-CH2CH2COOH

Boc-NH-PEG2-CH2CH2COOH is a PEG-based linker for PROTACs, facilitating the conjugation of two essential ligands necessary for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Catalog No. T14737Cas No. 1365655-91-9

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Boc-NH-PEG2-CH2CH2COOH

Catalog No. T14737Cas No. 1365655-91-9

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Pack Size	Price	Availability	Quantity
100 mg	Inquiry	7-10 days
500 mg	Inquiry	7-10 days

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Product Introduction

Bioactivity

Description	Boc-NH-PEG2-CH2CH2COOH is a PEG-based linker for PROTACs, facilitating the conjugation of two essential ligands necessary for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
In vitro	PROTACs consist of two distinct ligands connected by a linker; one ligand binds to an E3 ubiquitin ligase, while the other targets a specific protein. By leveraging the intracellular ubiquitin-proteasome system, PROTACs facilitate the selective degradation of target proteins.

Chemical Properties

Molecular Weight	277.31
Formula	C₁₂H₂₃NO₆
Cas No.	1365655-91-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Boc-NH-PEG2-CH2CH2COOHBoc-NH-PEG-2-CH2CH2COOHBocNHPEG2CH2CH2COOHBoc NH PEG2 CH2CH2COOH