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Ly93

Name: Ly93
Brand: TargetMol
SKU: T15822
Price: 99 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T15822Cas No. 1883528-69-5

Ly93 is a selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor (IC50: 91 nM) used for studying atherosclerosis.

Ly93

Purity: 99.88%

Catalog No. T15822Cas No. 1883528-69-5

Ly93 is a selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor (IC50: 91 nM) used for studying atherosclerosis.

Pack Size	Price	Availability	Quantity
1 mg	$99	In Stock
1 mL x 10 mM (in DMSO)	$135	In Stock

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Purity:99.88%

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COA LCMS

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	Ly93 is a selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor (IC50: 91 nM) used for studying atherosclerosis.
In vivo	Pharmacokinetic characterization of Ly93 conducted in C57BL/6J mice suggests oral efficacy of Ly93. As an effective selective SMS2 inhibitor, Ly93 (100 mg/kg, i.g. once daily for 7 days) significantly reduced plasma SM levels in C57BL/6J mice[1].

Chemical Properties

Molecular Weight	332.4
Formula	C₂₁H₂₀N₂O₂
Cas No.	1883528-69-5

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 80 mg/mL (240.67 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0084 mL	15.0421 mL	30.0842 mL	150.4212 mL
5 mM	0.6017 mL	3.0084 mL	6.0168 mL	30.0842 mL
10 mM	0.3008 mL	1.5042 mL	3.0084 mL	15.0421 mL
20 mM	0.1504 mL	0.7521 mL	1.5042 mL	7.5211 mL
50 mM	0.0602 mL	0.3008 mL	0.6017 mL	3.0084 mL
100 mM	0.0301 mL	0.1504 mL	0.3008 mL	1.5042 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Ly-93Ly93