Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MS2177 is a potent and selective inhibitor of SETD8, the only methyltransferase known to catalyze monomethylation of histone H4 lysine 20 (H4K20). MS2177 has an in vitro IC50 of 1.9 μM (σ = 1.05 μM, n = 4) in ascintillation proximity assay. Binding of MS2177 to SETD8 was confirmed by isothermal titration calorimetry (ITC), having a KD of 1.3 μM.
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Description | MS2177 is a potent and selective inhibitor of SETD8, the only methyltransferase known to catalyze monomethylation of histone H4 lysine 20 (H4K20). MS2177 has an in vitro IC50 of 1.9 μM (σ = 1.05 μM, n = 4) in ascintillation proximity assay. Binding of MS2177 to SETD8 was confirmed by isothermal titration calorimetry (ITC), having a KD of 1.3 μM. |
Synonyms | MS 2177, MS-2177 |
Molecular Weight | 442.61 |
Formula | C24H38N6O2 |
CAS No. | T28114 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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MS2177 T28114 MS 2177 MS-2177 inhibitor inhibit