Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Methoxy-X04, a derivative of Congo red and Chrysamine-G, is a brain-permeable fluorescent probe for amyloid-β (Aβ).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 33.00 | |
5 mg | In stock | $ 76.00 | |
10 mg | In stock | $ 132.00 | |
25 mg | In stock | $ 263.00 | |
50 mg | In stock | $ 463.00 | |
100 mg | In stock | $ 683.00 | |
500 mg | In stock | $ 1,450.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 117.00 |
Description | Methoxy-X04, a derivative of Congo red and Chrysamine-G, is a brain-permeable fluorescent probe for amyloid-β (Aβ). |
In vitro | In in vitro binding studies, compared with Chrysamine-G (Ki = 25.3 nM), Methoxy-X04 exhibited similar binding affinity for Aβ fibrils (Ki = 26.8 nM) [1]. On brain slices of 12-month-old APP-PS1 (dE9) mice, 145 μM Methoxy-X04 was used for labeling fibrillary amyloid deposits [3]. |
In vivo | In PS1/APP mice, a single i.v. injection of 5 to 10 mg/kg Methoxy-X04 distinguished individual plaques from brain fluorescent images, within 30 to 60 min after treatment. A single i.p. injection of 10 mg/kg Methoxy-X04 also produced high contrast images of plaques and cerebrovascular amyloid in PS1/APP mouse brains [1]. |
Molecular Weight | 344.4 |
Formula | C23H20O3 |
CAS No. | 863918-78-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 3.44 mg/mL (10 mM)
You can also refer to dose conversion for different animals. More
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