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SMS2-IN-1

SMS2-IN-1 is an effective and highly selective sphingomyelin synthetase 2 (SMS2) inhibitor with IC50 of 6.5 nM and Kd of 37 nM. Sms2-in-1 is 150 times more selective to SMS2 than SMS1 (IC50 is 1000 nM).

Catalog No. T12938Cas No. 2098890-15-2

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SMS2-IN-1

Catalog No. T12938Cas No. 2098890-15-2

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Pack Size	Price	Availability
5 mg	$373	Backorder
50 mg	$1,980	Backorder
100 mg	$2,500	Backorder

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Product Introduction

Bioactivity

Description	SMS2-IN-1 is an effective and highly selective sphingomyelin synthetase 2 (SMS2) inhibitor with IC50 of 6.5 nM and Kd of 37 nM. Sms2-in-1 is 150 times more selective to SMS2 than SMS1 (IC50 is 1000 nM).
Targets&IC50	SMS2:6.5 nM

Chemical Properties

Molecular Weight	681.67
Formula	C₃₄H₃₇F₆N₃O₅
Cas No.	2098890-15-2

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 24.9 mg/mL (36.6 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4670 mL	7.3349 mL	14.6699 mL	73.3493 mL
5 mM	0.2934 mL	1.4670 mL	2.9340 mL	14.6699 mL
10 mM	0.1467 mL	0.7335 mL	1.4670 mL	7.3349 mL
20 mM	0.0733 mL	0.3667 mL	0.7335 mL	3.6675 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

SMS2 IN 1SMS2-IN-1SMS2IN1SMS-2-IN-1