(S)-CE-123 is an innovative and highly selective atypical dopamine transporter (DAT) inhibitor, exhibiting an EC 50 of 2.76 μM in uptake inhibition assays performed in HEK293 cells with stable expression of human DAT isoforms. As a Modafinil analogue, (S)-CE-123 can cross the blood–brain barrier and enhances cognitive and motivational functions in experimental animals [1] [2].

(S)-CE-123 administered at doses of 6.0, 12.0, and 24.0 mg/kg via intraperitoneal injection 30 minutes prior to testing significantly mitigated the effects of TBZ (Tetrabenazine) on lever pressing and food intake. When administered alone, (S)-CE-123 produced no significant effects compared to vehicle-treated rats [1]. Animal Model: Trained rats (adult male Sprague-Dawley rats) [1] Dosage: 6.0, 12.0, 24.0 mg/kg Administration: IP; 30 min before testing Result: Attenuated the effects of TBZ (1.0 mg/kg) on lever pressing and chow intake.