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ALLM
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Catalog No. T14187Cas No. 110115-07-6
Alias Calpain inhibitor II
ALLM (Calpain inhibitor II), a potent calpain and cathepsin protease inhibitor, not only prevents neuronal cell death but also enhances chronic neurological function following spinal cord injury (SCI)[1][2].
ALLM
🥰Excellent
Catalog No. T14187Alias Calpain inhibitor IICas No. 110115-07-6
ALLM (Calpain inhibitor II), a potent calpain and cathepsin protease inhibitor, not only prevents neuronal cell death but also enhances chronic neurological function following spinal cord injury (SCI)[1][2].
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Product Introduction
Bioactivity
Chemical Properties
| Description | ALLM (Calpain inhibitor II), a potent calpain and cathepsin protease inhibitor, not only prevents neuronal cell death but also enhances chronic neurological function following spinal cord injury (SCI)[1][2]. |
| In vivo | ALLM (Calpain inhibitor II) (0.5 mg/kg) is administered every 24 hours for 5 days following spinal cord injury (SCI), inhibiting calpain activation without affecting caspase 3. ALLM (0.05-2.5 mg/kg; i.p.; every 24 hours for 1 week) reduces motor disturbances post-SCI and prevents neuronal cell death[2]. |
| Alias | Calpain inhibitor II |
| Molecular Weight | 401.56 |
| Formula | C19H35N3O4S |
| Cas No. | 110115-07-6 |
| Relative Density. | 1.076 g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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