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Anti-AXL Monoclonal Antibody-PE

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Catalog No. TMAZ-0122P
Alias Tyrosine-protein kinase receptor UFO, AXL oncogene

Anti-AXL Monoclonal Antibody-PE is a Biotin-conjugated rabbit antibody targeting AXL. Anti-AXL Monoclonal Antibody-PE can be used in ELISA, FACS, IF.

Anti-AXL Monoclonal Antibody-PE

Anti-AXL Monoclonal Antibody-PE

😃Good
Catalog No. TMAZ-0122PAlias Tyrosine-protein kinase receptor UFO, AXL oncogene
Anti-AXL Monoclonal Antibody-PE is a Biotin-conjugated rabbit antibody targeting AXL. Anti-AXL Monoclonal Antibody-PE can be used in ELISA, FACS, IF.
Pack SizePriceAvailabilityQuantity
25 μg247 €12 days
50 μg408 €12 days
100 μg612 €12 days
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Product Introduction

Bioactivity
Description
Anti-AXL Monoclonal Antibody-PE is a Biotin-conjugated rabbit antibody targeting AXL. Anti-AXL Monoclonal Antibody-PE can be used in ELISA, FACS, IF.
AliasTyrosine-protein kinase receptor UFO, AXL oncogene
Ig Type
Rabbit monoclonal IgG
Reactivity
Human
Verified Activity
Flow cytometry analysis of AXL overexpressed 312F cells with TMAZ-0122P, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line).
Application
ELISA, FACS, IF
Recommended Dose
0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA
Antibody Type
Monoclonal
Host SpeciesRabbit
Subcellular LocalizationSingle-pass type I membrane
ConstructionThis antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of AXL protein.
PurificationProtein A Affinity Purified
AppearanceLiquid
Formulation0.22 μm filtered solution in 20 mM HEPES7.4, 150 mM NaCl, 50% glycerol and 0.03% proclin.
Purity> 95% as determined by SDS-PAGE.
Research BackgroundReceptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, AXL binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response|(Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope|(Microbial infection) Acts as a receptor for Ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope|(Microbial infection) Promotes Zika virus entry in glial cells, Sertoli cells and astrocytes (PubMed: 28076778, PubMed: 29379210, PubMed: 31311882). Additionally, Zika virus potentiates AXL kinase activity to antagonize type I interferon signaling and thereby promotes infection (PubMed: 28076778). Interferon signaling inhibition occurs via an SOCS1-dependent mechanism (PubMed: 29379210)
Related Conjugates and Formulations
Conjucates
PE
Others Formats
Biotin/APC/AF488/AF555/AF647
Antibody Types Available
1
Antigen Details
Immunogen
AXL
Antigen Species
Human
Gene ID
558
Uniprot ID
Biology Area
Cancer Research
Chemical Properties
Molecular Weight150 kDa
Stability & Storage
Stability & StorageFor unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze.
TransportFor unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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