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Anti-CD46 Monoclonal Antibody-AF488
Anti-CD46 Monoclonal Antibody-AF488
Anti-CD46 Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting CD46. Anti-CD46 Monoclonal Antibody-AF488 can be used in ELISA, FACS, IF.
Catalog No. TMAZ-0191A4
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Anti-CD46 Monoclonal Antibody-AF488
Catalog No. TMAZ-0191A4Alias Trophoblast leukocyte common antigen, TLX, Membrane cofactor protein
Anti-CD46 Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting CD46. Anti-CD46 Monoclonal Antibody-AF488 can be used in ELISA, FACS, IF.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 μg | $325 | 12 days | |
| 50 μg | $535 | 12 days | |
| 100 μg | $805 | 12 days |
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Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-CD46 Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting CD46. Anti-CD46 Monoclonal Antibody-AF488 can be used in ELISA, FACS, IF. |
| Alias | Trophoblast leukocyte common antigen, TLX, Membrane cofactor protein |
| Ig Type | Rabbit monoclonal IgG |
| Reactivity | Human |
| Verified Activity | Flow cytometry analysis of CD46 overexpressed 322F cells with TMAZ-0191A4, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line). |
| Application | ELISA, FACS, IF |
| Recommended Dose | 0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Single-pass type I membrane |
| Construction | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of CD46 protein. |
| Purification | Protein A Affinity Purified |
| Appearance | Liquid |
| Formulation | 0.22 μm filtered solution in 20 mM HEPES7.4, 150 mM NaCl, 50% glycerol and 0.03% proclin. |
| Purity | > 95% as determined by SDS-PAGE. |
| Research Background | Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity|(Microbial infection) A number of viral and bacterial pathogens seem to bind MCP in order to exploit its immune regulation property and directly induce an immunosuppressive phenotype in T-cells|(Microbial infection) Acts as a receptor for Adenovirus subgroup B2 and Ad3|(Microbial infection) Acts as a receptor for cultured Measles virus|(Microbial infection) Acts as a receptor for Herpesvirus 6/HHV-6|(Microbial infection) May act as a receptor for pathogenic bacteria Neisseria and Streptococcus pyogenes (PubMed: 11260136, PubMed: 11971006, PubMed: 7708671, PubMed: 9379894) |
| Conjucates | AF488 |
| Others Formats | Biotin/APC/PE/AF555/AF647 |
| Antibody Types Available | 4 |
| Immunogen | CD46 |
| Antigen Species | Human |
| Gene ID | 4179 |
| Uniprot ID | |
| Biology Area | Drug Target |
| Molecular Weight | 150 kDa |
Stability & Storage
| Stability & Storage | For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze. |
| Transport | For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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