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Anti-CD46 Monoclonal Antibody-AF488
Catalog No. TMAZ-0191A4
Alias Trophoblast leukocyte common antigen, TLX, Membrane cofactor protein
Anti-CD46 Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting CD46. Anti-CD46 Monoclonal Antibody-AF488 can be used in ELISA, FACS, IF.
Anti-CD46 Monoclonal Antibody-AF488
Anti-CD46 Monoclonal Antibody-AF488
Catalog No. TMAZ-0191A4Alias Trophoblast leukocyte common antigen, TLX, Membrane cofactor protein
Anti-CD46 Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting CD46. Anti-CD46 Monoclonal Antibody-AF488 can be used in ELISA, FACS, IF.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 μg | $325 | 12 days | |
| 50 μg | $535 | 12 days | |
| 100 μg | $805 | 12 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-CD46 Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting CD46. Anti-CD46 Monoclonal Antibody-AF488 can be used in ELISA, FACS, IF. |
| Alias | Trophoblast leukocyte common antigen, TLX, Membrane cofactor protein |
| Ig Type | Rabbit monoclonal IgG |
| Reactivity | Human |
| Verified Activity | Flow cytometry analysis of CD46 overexpressed 322F cells with TMAZ-0191A4, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line). |
| Application | ELISA, FACS, IF |
| Recommended Dose | 0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Single-pass type I membrane |
| Construction | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of CD46 protein. |
| Purification | Protein A Affinity Purified |
| Appearance | Liquid |
| Formulation | 0.22 μm filtered solution in 20 mM HEPES7.4, 150 mM NaCl, 50% glycerol and 0.03% proclin. |
| Purity | > 95% as determined by SDS-PAGE. |
| Research Background | Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity|(Microbial infection) A number of viral and bacterial pathogens seem to bind MCP in order to exploit its immune regulation property and directly induce an immunosuppressive phenotype in T-cells|(Microbial infection) Acts as a receptor for Adenovirus subgroup B2 and Ad3|(Microbial infection) Acts as a receptor for cultured Measles virus|(Microbial infection) Acts as a receptor for Herpesvirus 6/HHV-6|(Microbial infection) May act as a receptor for pathogenic bacteria Neisseria and Streptococcus pyogenes (PubMed: 11260136, PubMed: 11971006, PubMed: 7708671, PubMed: 9379894) |
| Conjucates | AF488 |
| Others Formats | Biotin/APC/PE/AF555/AF647 |
| Antibody Types Available | 4 |
| Immunogen | CD46 |
| Antigen Species | Human |
| Gene ID | 4179 |
| Uniprot ID | |
| Biology Area | Drug Target |
| Molecular Weight | 150 kDa |
Stability & Storage
| Stability & Storage | For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze. |
| Transport | For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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