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Anti-CD47 Monoclonal Antibody-AF488
Catalog No. TMAZ-0052A4
Alias Protein MER6, Leukocyte surface antigen CD47, Integrin-associated protein, Antigenic surface determinant protein OA3
Anti-CD47 Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting CD47. Anti-CD47 Monoclonal Antibody-AF488 can be used in ELISA, FACS.
Anti-CD47 Monoclonal Antibody-AF488
Anti-CD47 Monoclonal Antibody-AF488
Catalog No. TMAZ-0052A4Alias Protein MER6, Leukocyte surface antigen CD47, Integrin-associated protein, Antigenic surface determinant protein OA3
Anti-CD47 Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting CD47. Anti-CD47 Monoclonal Antibody-AF488 can be used in ELISA, FACS.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 μg | $415 | 12 days | |
| 50 μg | $690 | 12 days | |
| 100 μg | $1,035 | 12 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-CD47 Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting CD47. Anti-CD47 Monoclonal Antibody-AF488 can be used in ELISA, FACS. |
| Alias | Protein MER6, Leukocyte surface antigen CD47, Integrin-associated protein, Antigenic surface determinant protein OA3 |
| Ig Type | Rabbit monoclonal IgG |
| Reactivity | Human |
| Verified Activity | Flow cytometry analysis of CD47 overexpressed 293F cells with TMAZ-0052A4BI, followed by goat anti-rabbit IgG-ABflo 647 (red). The isotype control is rabbit IgG (black line). |
| Application | ELISA, FACS |
| Recommended Dose | 0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Secreted |
| Construction | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of CD47 protein. |
| Purification | Protein A Affinity Purified |
| Appearance | Liquid |
| Formulation | 0.22 μm filtered solution in 20 mM HEPES7.4, 150 mM NaCl, 50% glycerol and 0.03% proclin. |
| Purity | > 95% as determined by SDS-PAGE. |
| Research Background | Adhesive protein that mediates cell-to-cell interactions (PubMed: 11509594, PubMed: 15383453). Acts as a receptor for thrombospondin THBS1 and as modulator of integrin signaling through the activation of heterotrimeric G proteins (PubMed: 19004835, PubMed: 7691831, PubMed: 8550562). Involved in signal transduction, cardiovascular homeostasis, inflammation, apoptosis, angiogenesis, cellular self-renewal, and immunoregulation (PubMed: 11509594, PubMed: 15383453, PubMed: 19004835, PubMed: 27742621, PubMed: 32679764, PubMed: 7691831, PubMed: 8550562). Plays a role in modulating pulmonary endothelin EDN1 signaling (PubMed: 27742621). Modulates nitrous oxide (NO) signaling, in response to THBS1, hence playing a role as a pressor agent, supporting blood pressure (By similarity). Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells (PubMed: 11509594). Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation (PubMed: 15383453). Positively modulates FAS-dependent apoptosis in T-cells, perhaps by enhancing FAS clustering (By similarity). Plays a role in suppressing angiogenesis and may be involved in metabolic dysregulation during normal aging (PubMed: 32679764). In response to THBS1, negatively modulates wound healing (By similarity). Inhibits stem cell self-renewal, in response to THBS1, probably by regulation of the stem cell transcription factors POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 (By similarity). May play a role in membrane transport and/or integrin dependent signal transduction (PubMed: 7691831). May prevent premature elimination of red blood cells (By similarity) |
| Conjucates | AF488 |
| Others Formats | Biotin/APC/PE/AF555/AF647 |
| Antibody Types Available | 1 |
| Immunogen | CD47 |
| Antigen Species | Human |
| Gene ID | 961 |
| Uniprot ID | |
| Biology Area | Immunology Research |
| Molecular Weight | 150 kDa |
Stability & Storage
| Stability & Storage | For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze. |
| Transport | For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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