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Anti-CD84 Monoclonal Antibody-AF488
Catalog No. TMAZ-0049A4
Alias SLAM family member 5, Signaling lymphocytic activation molecule 5, Leukocyte differentiation antigen CD84, Hly9-beta, Cell surface antigen MAX.3
Anti-CD84 Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting CD84. Anti-CD84 Monoclonal Antibody-AF488 can be used in ELISA, FACS, IF.
Anti-CD84 Monoclonal Antibody-AF488
Anti-CD84 Monoclonal Antibody-AF488
Catalog No. TMAZ-0049A4Alias SLAM family member 5, Signaling lymphocytic activation molecule 5, Leukocyte differentiation antigen CD84, Hly9-beta, Cell surface antigen MAX.3
Anti-CD84 Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting CD84. Anti-CD84 Monoclonal Antibody-AF488 can be used in ELISA, FACS, IF.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 μg | $370 | 12 days | |
| 50 μg | $610 | 12 days | |
| 100 μg | $915 | 12 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-CD84 Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting CD84. Anti-CD84 Monoclonal Antibody-AF488 can be used in ELISA, FACS, IF. |
| Alias | SLAM family member 5, Signaling lymphocytic activation molecule 5, Leukocyte differentiation antigen CD84, Hly9-beta, Cell surface antigen MAX.3 |
| Ig Type | Rabbit monoclonal IgG |
| Reactivity | Human |
| Verified Activity | Flow cytometry analysis of CD84 overexpressed 293F cells with TMAZ-0049A4BI, which was counjucated with SA-PE (red). The WT 293F control is black line. |
| Application | ELISA, FACS, IF |
| Recommended Dose | 0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Single-pass type I membrane |
| Construction | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of CD84 protein. |
| Purification | Protein A Affinity Purified |
| Appearance | Liquid |
| Formulation | 0.22 μm filtered solution in PBS. |
| Purity | > 95% as determined by SDS-PAGE. |
| Research Background | Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Can mediate natural killer (NK) cell cytotoxicity dependent on SH2D1A and SH2D1B (By similarity). Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seem be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A-dependent pathway. May serve as a marker for hematopoietic progenitor cells (PubMed: 11564780, PubMed: 12115647, PubMed: 12928397, PubMed: 12962726, PubMed: 16037392) Required for a prolonged T-cell: B-cell contact, optimal T follicular helper function, and germinal center formation. In germinal centers involved in maintaining B-cell tolerance and in preventing autoimmunity (By similarity). In mast cells negatively regulates high affinity immunoglobulin epsilon receptor signaling; independent of SH2D1A and SH2D1B but implicating FES and PTPN6/SHP-1 (PubMed: 22068234). In macrophages enhances LPS-induced MAPK phosphorylation and NF-kappaB activation and modulates LPS-induced cytokine secretion; involving ITSM 2 (By similarity). Positively regulates macroautophagy in primary dendritic cells via stabilization of IRF8; inhibits TRIM21-mediated proteasomal degradation of IRF8 (PubMed: 29434592) |
| Conjucates | AF488 |
| Others Formats | Biotin/APC/PE/AF555/AF647 |
| Antibody Types Available | 2 |
| Immunogen | CD84 |
| Antigen Species | Human |
| Gene ID | 8832 |
| Uniprot ID | |
| Biology Area | Immunology Research |
| Molecular Weight | 150 kDa |
Stability & Storage
| Stability & Storage | For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze. |
| Transport | For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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