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Anti-TYRO3 Monoclonal Antibody-AF488
Catalog No. TMAZ-0193A4
Alias Tyrosine-protein kinase TIF, Tyrosine-protein kinase SKY, Tyrosine-protein kinase RSE, Tyrosine-protein kinase receptor TYRO3, Tyrosine-protein kinase DTK, Tyrosine-protein kinase BYK
Anti-TYRO3 Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting TYRO3. Anti-TYRO3 Monoclonal Antibody-AF488 can be used in ELISA, FACS, IF.
Anti-TYRO3 Monoclonal Antibody-AF488
Anti-TYRO3 Monoclonal Antibody-AF488
Catalog No. TMAZ-0193A4Alias Tyrosine-protein kinase TIF, Tyrosine-protein kinase SKY, Tyrosine-protein kinase RSE, Tyrosine-protein kinase receptor TYRO3, Tyrosine-protein kinase DTK, Tyrosine-protein kinase BYK
Anti-TYRO3 Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting TYRO3. Anti-TYRO3 Monoclonal Antibody-AF488 can be used in ELISA, FACS, IF.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 μg | $570 | 12 days | |
| 50 μg | $945 | 12 days | |
| 100 μg | $1,415 | 12 days |
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Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-TYRO3 Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting TYRO3. Anti-TYRO3 Monoclonal Antibody-AF488 can be used in ELISA, FACS, IF. |
| Alias | Tyrosine-protein kinase TIF, Tyrosine-protein kinase SKY, Tyrosine-protein kinase RSE, Tyrosine-protein kinase receptor TYRO3, Tyrosine-protein kinase DTK, Tyrosine-protein kinase BYK |
| Ig Type | Rabbit monoclonal IgG |
| Reactivity | Human |
| Verified Activity | Flow cytometry analysis of TYRO3 overexpressed 295F cells with TMAZ-0193A4, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line). |
| Application | ELISA, FACS, IF |
| Recommended Dose | 0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Single-pass type I membrane |
| Construction | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of TYRO3 protein. |
| Purification | Protein A Affinity Purified |
| Appearance | Liquid |
| Formulation | 0.22 μm filtered solution in 20 mM HEPES7.4, 150 mM NaCl, 50% glycerol and 0.03% proclin. |
| Purity | > 95% as determined by SDS-PAGE. |
| Research Background | Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3|(Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope|(Microbial infection) Acts as a receptor for Ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope |
| Conjucates | AF488 |
| Others Formats | Biotin/APC/PE/AF555/AF647 |
| Antibody Types Available | 1 |
| Immunogen | TYRO3 |
| Antigen Species | Human |
| Gene ID | 7301 |
| Uniprot ID | |
| Biology Area | Drug Target |
| Molecular Weight | 150 kDa |
Stability & Storage
| Stability & Storage | For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze. |
| Transport | For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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