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Antiproliferative agent-48
Compound PC-A1 (Antiproliferative agent-48) demonstrates selective antiproliferative activity against triple-negative breast cancer (TNBC) cells [1].
Catalog No. T85700Cas No. 1621594-62-4
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Antiproliferative agent-48
Catalog No. T85700Cas No. 1621594-62-4
Compound PC-A1 (Antiproliferative agent-48) demonstrates selective antiproliferative activity against triple-negative breast cancer (TNBC) cells [1].
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks |
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Bioactivity
Chemical Properties
| Description | Compound PC-A1 (Antiproliferative agent-48) demonstrates selective antiproliferative activity against triple-negative breast cancer (TNBC) cells [1]. |
| In vitro | Antiproliferative agent-48, at concentrations ranging from 5-50 μM, inhibits the proliferation of various cancer cell lines including MDA-MB-231 (TNBC), MCF-7, A549, and KB (HeLa derivative) as well as KB-VIN, with IC50 values of 5.4, 18, 19, 15, and 19 μM respectively [1]. This compound also induces cell cycle arrest at the G2/M phase in MDA-MB-231 cells [1]. In cell proliferation experiments conducted over 72 hours, Antiproliferative agent-48 demonstrated significant inhibition of cellular proliferation at micromolar levels [1]. Cell cycle analysis revealed the blockade of cells in the G2/M phase after 24 hours of incubation [1]. |
| Molecular Weight | 313.19 |
| Formula | C14H17BrO3 |
| Cas No. | 1621594-62-4 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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