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Antitumor agent-171
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Catalog No. T88683Cas No. 3003004-76-7
Antitumor agent-171 (Compound 35) acts as an inhibitor of the β-catenin/BCL9 interaction, with an IC50 of 1.61 μM. It suppresses the expression of the axin2 gene, demonstrating an IC50 value of 0.84 μM, and exhibits high affinity for β-catenin with a Kd of 0.63 μM. Additionally, Antitumor agent-171 inhibits the viability of HCT116 cells with an IC50 of 4.39 μM. It activates T cells, enhances antigen presentation, and shows antitumor activity and favorable pharmacokinetic properties in murine models.
Antitumor agent-171
😃Good
Catalog No. T88683Cas No. 3003004-76-7
Antitumor agent-171 (Compound 35) acts as an inhibitor of the β-catenin/BCL9 interaction, with an IC50 of 1.61 μM. It suppresses the expression of the axin2 gene, demonstrating an IC50 value of 0.84 μM, and exhibits high affinity for β-catenin with a Kd of 0.63 μM. Additionally, Antitumor agent-171 inhibits the viability of HCT116 cells with an IC50 of 4.39 μM. It activates T cells, enhances antigen presentation, and shows antitumor activity and favorable pharmacokinetic properties in murine models.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks |
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Chemical Properties
| Description | Antitumor agent-171 (Compound 35) acts as an inhibitor of the β-catenin/BCL9 interaction, with an IC50 of 1.61 μM. It suppresses the expression of the axin2 gene, demonstrating an IC50 value of 0.84 μM, and exhibits high affinity for β-catenin with a Kd of 0.63 μM. Additionally, Antitumor agent-171 inhibits the viability of HCT116 cells with an IC50 of 4.39 μM. It activates T cells, enhances antigen presentation, and shows antitumor activity and favorable pharmacokinetic properties in murine models. |
| Molecular Weight | 643.78 |
| Formula | C35H45N7O5 |
| Cas No. | 3003004-76-7 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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