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BD-Oligo

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Catalog No. T202001Cas No. 1357578-02-9
Alias BoDipy-Oligomer, BDOligo, BD Oligo

BD-Oligo is a promising fluorescent sensor designed for detecting Aβ oligomers. It effectively monitors the dynamics of these oligomers during fibril formation in vitro and shows potential for in vivo staining in Alzheimer's disease (AD) mouse models. The sensing mechanism is facilitated through π-π stacking interactions and hydrogen bonding between BD-Oligo and the exposed hydrophobic regions of Aβ oligomers, as confirmed by computational techniques. Furthermore, BD-Oligo can cross the blood-brain barrier (BBB) to detect oligomers in the brains of AD transgenic mice without causing toxicity.

BD-Oligo

BD-Oligo

😃Good
Catalog No. T202001Alias BoDipy-Oligomer, BDOligo, BD OligoCas No. 1357578-02-9
BD-Oligo is a promising fluorescent sensor designed for detecting Aβ oligomers. It effectively monitors the dynamics of these oligomers during fibril formation in vitro and shows potential for in vivo staining in Alzheimer's disease (AD) mouse models. The sensing mechanism is facilitated through π-π stacking interactions and hydrogen bonding between BD-Oligo and the exposed hydrophobic regions of Aβ oligomers, as confirmed by computational techniques. Furthermore, BD-Oligo can cross the blood-brain barrier (BBB) to detect oligomers in the brains of AD transgenic mice without causing toxicity.
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Product Introduction

Bioactivity
Description
BD-Oligo is a promising fluorescent sensor designed for detecting Aβ oligomers. It effectively monitors the dynamics of these oligomers during fibril formation in vitro and shows potential for in vivo staining in Alzheimer's disease (AD) mouse models. The sensing mechanism is facilitated through π-π stacking interactions and hydrogen bonding between BD-Oligo and the exposed hydrophobic regions of Aβ oligomers, as confirmed by computational techniques. Furthermore, BD-Oligo can cross the blood-brain barrier (BBB) to detect oligomers in the brains of AD transgenic mice without causing toxicity.
AliasBoDipy-Oligomer, BDOligo, BD Oligo
Chemical Properties
Molecular Weight571.64
FormulaC25H24BCl3F2N2O4
Cas No.1357578-02-9
Storage & Solubility Information
Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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