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BML-260

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Catalog No. T89165Cas No. 101439-76-3

BML-260 is a potent dual-specificity inhibitor of the phosphatases JSP-1 and DUSP22. It can activate UCP1 and induce thermogenesis in adipocytes independently of JSP-1. The effects of BML-260 on adipocytes partially occur through the activation of the CREB, STAT3, and PPAR signaling pathways. This compound is useful for research on inflammation, proliferative disorders associated with JNK signaling dysfunction, and obesity.

BML-260

BML-260

😃Good
Catalog No. T89165Cas No. 101439-76-3
BML-260 is a potent dual-specificity inhibitor of the phosphatases JSP-1 and DUSP22. It can activate UCP1 and induce thermogenesis in adipocytes independently of JSP-1. The effects of BML-260 on adipocytes partially occur through the activation of the CREB, STAT3, and PPAR signaling pathways. This compound is useful for research on inflammation, proliferative disorders associated with JNK signaling dysfunction, and obesity.
Pack SizePriceAvailabilityQuantity
10 mgInquiry10-14 weeks
50 mgInquiry10-14 weeks
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Product Introduction

Bioactivity
Description
BML-260 is a potent dual-specificity inhibitor of the phosphatases JSP-1 and DUSP22. It can activate UCP1 and induce thermogenesis in adipocytes independently of JSP-1. The effects of BML-260 on adipocytes partially occur through the activation of the CREB, STAT3, and PPAR signaling pathways. This compound is useful for research on inflammation, proliferative disorders associated with JNK signaling dysfunction, and obesity.
Chemical Properties
Molecular Weight341.4
FormulaC17H11NO3S2
Cas No.101439-76-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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