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c-di-AMP

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c-di-AMP

Catalog No. T10642Cas No. 54447-84-6

c-di-AMP (Cyclic diadenylate) is a STING agonist that binds to the transmembrane protein STING, thereby activating the TBK3-IRF3 signaling pathway.

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Pack Size	Price	Availability
25 mg	$1,330	6-8 weeks
50 mg	$1,730	6-8 weeks
100 mg	$2,500	6-8 weeks

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Product Introduction

Bioactivity

Description	c-di-AMP (Cyclic diadenylate) is a STING agonist that binds to the transmembrane protein STING, thereby activating the TBK3-IRF3 signaling pathway.
In vitro	c-di-AMP signaling is a central factor in many Gram-positive bacteria regulating cell wall synthesis, potassium ion channels, DNA repair, and biofilm formation. c-di-AMP is also essential for cell growth, survival, and virulence of several well-known human pathogenic bacteria [1]. c-di-AMP combines with model antigens, such as OVA or β-Gal, acts as a potent mucosal adjuvant stimulating both humoral and cellular responses [4].
Alias	Cyclic diadenylate, Cyclic-di-AMP

Chemical Properties

Molecular Weight	658.41
Formula	C20H24N10O12P2
Cas No.	54447-84-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 5.5 mg/mL (8.35 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	1.5188 mL	7.5941 mL	15.1881 mL	75.9405 mL
5 mM	0.3038 mL	1.5188 mL	3.0376 mL	15.1881 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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Keywords

c di AMPcdiAMPc-di-AMP