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CEP-751
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Catalog No. T202268Cas No. 156177-59-2
Alias KT-6587, KT6587, KT 6587, CEP751, CEP 751
CEP-751 (also known as KT-6587) is a potent Trk inhibitor. It exhibits significant growth inhibition in MBL cell line D283 (Day 39, P=0.031) and demonstrates moderate growth inhibition in IMR5 (P=0.062) and CHP-134 (P=0.049) cell lines. Additionally, CEP-751 induces apoptosis in CHP-134 tumors. It may be a useful compound for treating NBL or MBL. At a concentration of 100 nM, CEP-751 inhibits the receptor tyrosine kinase activity of neurotrophin receptors trkA, trkB, and trkC. It also shows antitumor effects on tumors derived from trkA-transfected NIH3T3 cells.
CEP-751
😃Good
Catalog No. T202268Alias KT-6587, KT6587, KT 6587, CEP751, CEP 751Cas No. 156177-59-2
CEP-751 (also known as KT-6587) is a potent Trk inhibitor. It exhibits significant growth inhibition in MBL cell line D283 (Day 39, P=0.031) and demonstrates moderate growth inhibition in IMR5 (P=0.062) and CHP-134 (P=0.049) cell lines. Additionally, CEP-751 induces apoptosis in CHP-134 tumors. It may be a useful compound for treating NBL or MBL. At a concentration of 100 nM, CEP-751 inhibits the receptor tyrosine kinase activity of neurotrophin receptors trkA, trkB, and trkC. It also shows antitumor effects on tumors derived from trkA-transfected NIH3T3 cells.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks |
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Chemical Properties
| Description | CEP-751 (also known as KT-6587) is a potent Trk inhibitor. It exhibits significant growth inhibition in MBL cell line D283 (Day 39, P=0.031) and demonstrates moderate growth inhibition in IMR5 (P=0.062) and CHP-134 (P=0.049) cell lines. Additionally, CEP-751 induces apoptosis in CHP-134 tumors. It may be a useful compound for treating NBL or MBL. At a concentration of 100 nM, CEP-751 inhibits the receptor tyrosine kinase activity of neurotrophin receptors trkA, trkB, and trkC. It also shows antitumor effects on tumors derived from trkA-transfected NIH3T3 cells. |
| Alias | KT-6587, KT6587, KT 6587, CEP751, CEP 751 |
| Molecular Weight | 453.49 |
| Formula | C27H23N3O4 |
| Cas No. | 156177-59-2 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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