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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,520 | 6-8 weeks | |
50 mg | $1,980 | 6-8 weeks | |
100 mg | $2,500 | 6-8 weeks |
Description | DHQZ 36 is a potent retrograde trafficking inhibitor. It has potent anti-parasite activity. DHQZ 36 inhibits Leishmania amazonensis infection in macrophages (EC50: 13.63 μM). |
Targets&IC50 | Leishmania amazonensis:(EC50)13.63 μM |
In vitro | DHQZ 36 causes over 40% reduction in secreted of parasite proteins and it also causes a reversal in Leishmania induced suppression of IL-6 release by infected cells after LPS activation. With increasing concentrations of DHQZ 36, there is a significant diminution in the size of parasitophorous vacuoles (LPVs), vacuole sizes are reduced by 30% at 50 μM. Significant parasite loss is observed with as low as 5 μM after treatment with DHQZ 36. Parasites are unable to recover growth when treated with DHQZ 36 at concentrations at or above 12.5 μM. |
Molecular Weight | 384.44 |
Formula | C21H18F2N2OS |
Cas No. | 1542098-94-1 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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