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DHQZ 36

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DHQZ 36

Catalog No. T15110Cas No. 1542098-94-1

DHQZ 36 is a potent retrograde trafficking inhibitor. It has potent anti-parasite activity. DHQZ 36 inhibits Leishmania amazonensis infection in macrophages (EC50: 13.63 μM).

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Pack Size	Price	Availability
25 mg	$1,520	6-8 weeks
50 mg	$1,980	6-8 weeks
100 mg	$2,500	6-8 weeks

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Product Introduction

Bioactivity

Description	DHQZ 36 is a potent retrograde trafficking inhibitor. It has potent anti-parasite activity. DHQZ 36 inhibits Leishmania amazonensis infection in macrophages (EC50: 13.63 μM).
Targets&IC50	Leishmania amazonensis:（EC50）13.63 μM
In vitro	DHQZ 36 causes over 40% reduction in secreted of parasite proteins and it also causes a reversal in Leishmania induced suppression of IL-6 release by infected cells after LPS activation. With increasing concentrations of DHQZ 36, there is a significant diminution in the size of parasitophorous vacuoles (LPVs), vacuole sizes are reduced by 30% at 50 μM. Significant parasite loss is observed with as low as 5 μM after treatment with DHQZ 36. Parasites are unable to recover growth when treated with DHQZ 36 at concentrations at or above 12.5 μM.

Chemical Properties

Molecular Weight	384.44
Formula	C21H18F2N2OS
Cas No.	1542098-94-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Keywords

DHQZ 36DHQZ-36DHQZ36