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Gangliotetraose

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Catalog No. T82339Cas No. 75645-24-8
Alias Gg4

Gangliotetraose (Gg4), a tetrasccharide, predominantly comprises GM1 and its sialylated derivatives, which play a crucial role in modulating nuclear Ca2+ efflux and maintaining lower nuclear Ca2+ levels in differentiated neurons. Moreover, GM1 influences neuronal plasticity, repair mechanisms, and neurotrophin release in the brain [1] [2].

Gangliotetraose

Gangliotetraose

😃Good
Catalog No. T82339Alias Gg4Cas No. 75645-24-8
Gangliotetraose (Gg4), a tetrasccharide, predominantly comprises GM1 and its sialylated derivatives, which play a crucial role in modulating nuclear Ca2+ efflux and maintaining lower nuclear Ca2+ levels in differentiated neurons. Moreover, GM1 influences neuronal plasticity, repair mechanisms, and neurotrophin release in the brain [1] [2].
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Product Introduction

Bioactivity
Description
Gangliotetraose (Gg4), a tetrasccharide, predominantly comprises GM1 and its sialylated derivatives, which play a crucial role in modulating nuclear Ca2+ efflux and maintaining lower nuclear Ca2+ levels in differentiated neurons. Moreover, GM1 influences neuronal plasticity, repair mechanisms, and neurotrophin release in the brain [1] [2].
In vitro
Gangliotetraose (GM1) (10 μM; 1 h) enhances pheochromocytoma PC12 cell survival under hydrogen peroxide-induced oxidative stress (1 mM; 2 h), concurrently reducing reactive oxygen species accumulation and preventing oxidative inactivation of the Na+, K+-ATPase enzyme [3].
In vivo
Administered intraperitoneally at a dosage of 30 mg/kg on days 5, 11, 42, and 73, Gangliotetraose (GM1) promotes the regrowth of nigrostriatal dopaminergic neurons within the rat central nervous system following unilateral hemitransection [5].
AliasGg4
Chemical Properties
Molecular Weight707.63
FormulaC26H45NO21
Cas No.75645-24-8
Storage & Solubility Information
StorageShipping with blue ice.

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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