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Gangliotetraose

Name: Gangliotetraose
Brand: TargetMol
SKU: T82339
Rating: 4.5 (1 reviews)

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Catalog No. T82339Cas No. 75645-24-8

Alias Gg4

Gangliotetraose (Gg4), a tetrasccharide, predominantly comprises GM1 and its sialylated derivatives, which play a crucial role in modulating nuclear Ca2+ efflux and maintaining lower nuclear Ca2+ levels in differentiated neurons. Moreover, GM1 influences neuronal plasticity, repair mechanisms, and neurotrophin release in the brain [1] [2].

Gangliotetraose

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Catalog No. T82339Alias Gg4Cas No. 75645-24-8

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Product Introduction

Bioactivity

Description	Gangliotetraose (Gg4), a tetrasccharide, predominantly comprises GM1 and its sialylated derivatives, which play a crucial role in modulating nuclear Ca2+ efflux and maintaining lower nuclear Ca2+ levels in differentiated neurons. Moreover, GM1 influences neuronal plasticity, repair mechanisms, and neurotrophin release in the brain [1] [2].
In vitro	Gangliotetraose (GM1) (10 μM; 1 h) enhances pheochromocytoma PC12 cell survival under hydrogen peroxide-induced oxidative stress (1 mM; 2 h), concurrently reducing reactive oxygen species accumulation and preventing oxidative inactivation of the Na+, K+-ATPase enzyme [3].
In vivo	Administered intraperitoneally at a dosage of 30 mg/kg on days 5, 11, 42, and 73, Gangliotetraose (GM1) promotes the regrowth of nigrostriatal dopaminergic neurons within the rat central nervous system following unilateral hemitransection [5].
Alias	Gg4

Chemical Properties

Molecular Weight	707.63
Formula	C₂₆H₄₅NO₂₁
Cas No.	75645-24-8

Storage & Solubility Information

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Shipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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