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GlcN-6-P Synthase-IN-1

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Catalog No. T61784Cas No. 2447602-44-8

GlcN-6-P Synthase-IN-1 (Compound 4d) is a potent inhibitor of Glucosamine-6-phosphate (GlcN-6-P) synthase with an IC50 of 3.47 μM. This compound exhibits remarkable antimicrobial activity, excellent central nervous system penetration, and inhibits cytochrome P450, specifically the CYP3A4 isoform [1].

GlcN-6-P Synthase-IN-1

GlcN-6-P Synthase-IN-1

😃Good
Catalog No. T61784Cas No. 2447602-44-8
GlcN-6-P Synthase-IN-1 (Compound 4d) is a potent inhibitor of Glucosamine-6-phosphate (GlcN-6-P) synthase with an IC50 of 3.47 μM. This compound exhibits remarkable antimicrobial activity, excellent central nervous system penetration, and inhibits cytochrome P450, specifically the CYP3A4 isoform [1].
Pack SizePriceAvailabilityQuantity
25 mg$1,5206-8 weeks
50 mg$1,9806-8 weeks
100 mg$2,5006-8 weeks
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Product Introduction

Bioactivity
Description
GlcN-6-P Synthase-IN-1 (Compound 4d) is a potent inhibitor of Glucosamine-6-phosphate (GlcN-6-P) synthase with an IC50 of 3.47 μM. This compound exhibits remarkable antimicrobial activity, excellent central nervous system penetration, and inhibits cytochrome P450, specifically the CYP3A4 isoform [1].
In vitro
GlcN-6-P Synthase-IN-1 (Compound 4d) exhibits antimicrobial properties, with MIC values of 1 ± 0.15 μg/mL for S. aureus, 0.5 ± 0.15 μg/mL for B. subtilis, and 4 ± 0.33 μg/mL for both C. albicans and A. oryzae, demonstrating its effective inhibition of these microorganisms [1].
Chemical Properties
Molecular Weight391.49
FormulaC20H21N7S
Cas No.2447602-44-8
Storage & Solubility Information
StorageShipping with blue ice.

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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