GPR120 Agonist 4 (example 1), a GPR120 agonist, exhibits EC50 values of 1 μM for β-arrestin A and 0.35 μM for Calcium A. This compound is utilized in research related to type II diabetes mellitus [1].

GPR120:1 μM (EC 50 )

GPR120 Agonist 4 (example 1), at concentrations of 0.012-25 μM over 90 minutes, activates GPR120 in CHO-K1 GPR120 β-arrestin cells through the recruitment of β-arrestin [1]. Additionally, GPR120 Agonist 4 (0.012-25 μM, 90 min) facilitates calcium ion release in HEK293 cells overexpressing human GPR120, confirming its effectiveness in activating GPR120 [1].

GPR120 Agonist 4 (example 1), administered intraperitoneally at doses of 0.2/0.3/1/3/10 mg/kg for 15/30/45/60/90 minutes, promotes a dose-dependent reduction in glucose levels in a high-fat diet mouse model [1]. Furthermore, at doses of 1/3/10 mg/kg for the same time intervals, it inhibits the rise in glucose levels in a fasting mouse model in a dose-dependent manner [1].