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HMC-B17

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Catalog No. T86587Cas No. 2935913-83-8

HMC-B17 is a selective and orally bioavailable HPK1 inhibitor (IC50 = 1.39 nM) that enhances anti-PD-L1 efficacy. It significantly increases IL-2 secretion in Jurkat cells (EC50 = 11.56 nM) and can be utilized for cancer research [1].

HMC-B17

HMC-B17

😃Good
Catalog No. T86587Cas No. 2935913-83-8
HMC-B17 is a selective and orally bioavailable HPK1 inhibitor (IC50 = 1.39 nM) that enhances anti-PD-L1 efficacy. It significantly increases IL-2 secretion in Jurkat cells (EC50 = 11.56 nM) and can be utilized for cancer research [1].
Pack SizePriceAvailabilityQuantity
10 mgInquiry10-14 weeks
50 mgInquiry10-14 weeks
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Product Introduction

Bioactivity
Description
HMC-B17 is a selective and orally bioavailable HPK1 inhibitor (IC50 = 1.39 nM) that enhances anti-PD-L1 efficacy. It significantly increases IL-2 secretion in Jurkat cells (EC50 = 11.56 nM) and can be utilized for cancer research [1].
Chemical Properties
Molecular Weight427.54
FormulaC27H29N3O2
Cas No.2935913-83-8
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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