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Lactisole free acid

Name: Lactisole free acid
Brand: TargetMol
SKU: T89427
Rating: 4.5 (1 reviews)

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Catalog No. T89427Cas No. 13794-15-5

Lactisole free acid acts as a typical antagonist of sweet taste receptors, selectively targeting the T1R3 subunit. T1R3 functions as a glucose-sensing receptor. Additionally, Lactisole free acid inhibits insulin secretion induced by glucose in mouse islets.

Lactisole free acid

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Catalog No. T89427Cas No. 13794-15-5

Pack Size	Price	Availability	Quantity
10 mg	Inquiry	10-14 weeks
50 mg	Inquiry	10-14 weeks

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Product Introduction

Bioactivity

Description

In vitro

Lactisole free acid, at concentrations of 3-10 mM over a 48-hour exposure, suppresses insulin secretion induced by Acesulfame-K, Sucralose, and Glycyrrhizin in mouse pancreatic β-cells MIN6, with an IC 50 value of approximately 4 mM. Additionally, a 5 mM concentration of Lactisole free acid administered for the same duration attenuates the increase in cytoplasmic Ca2+ concentration ([Ca2+]c) triggered by Sucralose and Acesulfame-K, without affecting the rise in intracellular cAMP levels ([cAMP]c).

Chemical Properties

Molecular Weight	196.2
Formula	C₁₀H₁₂O₄
Cas No.	13794-15-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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