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LH1753

Catalog No. T88169Cas No. 2650492-10-5

LH1753 is an orally active inhibitor of L-cystine crystallization, with an EC50 of 29.5 nM. It is applicable in research related to Cystinuria.

LH1753

LH1753

Catalog No. T88169Cas No. 2650492-10-5
LH1753 is an orally active inhibitor of L-cystine crystallization, with an EC50 of 29.5 nM. It is applicable in research related to Cystinuria.
Pack SizePriceAvailabilityQuantity
10 mgInquiry10-14 weeks
50 mgInquiry10-14 weeks
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Product Introduction

Bioactivity
Description
LH1753 is an orally active inhibitor of L-cystine crystallization, with an EC50 of 29.5 nM. It is applicable in research related to Cystinuria.
In vivo
LH1753 (150 μmol/kg, administered orally, once daily for eight weeks) inhibits the formation of L-cystine stones but does not affect the growth of the cystinuria mouse model with Slc3a1 gene knockout [1].
Chemical Properties
Molecular Weight630.57
FormulaC22H44Cl4N6O2S2
Cas No.2650492-10-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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