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Lucitanib dihydrochloride
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Catalog No. T89507Cas No. 2108875-91-6
Alias E-3810 dihydrochloride, E3810 dihydrochloride, CO-3810 dihydrochloride, CO3810 dihydrochloride, AL3810 dihydrochloride, AL 3810 dihydrochloride
Lucitanib dihydrochloride (E-3810 dihydrochloride) is an efficient inhibitor of VEGFR1-3, FGFR1-3, and PDGFRalpha/β, useful in metastatic breast cancer research.
Lucitanib dihydrochloride
😃Good
Catalog No. T89507Alias E-3810 dihydrochloride, E3810 dihydrochloride, CO-3810 dihydrochloride, CO3810 dihydrochloride, AL3810 dihydrochloride, AL 3810 dihydrochlorideCas No. 2108875-91-6
Lucitanib dihydrochloride (E-3810 dihydrochloride) is an efficient inhibitor of VEGFR1-3, FGFR1-3, and PDGFRalpha/β, useful in metastatic breast cancer research.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Lucitanib dihydrochloride (E-3810 dihydrochloride) is an efficient inhibitor of VEGFR1-3, FGFR1-3, and PDGFRalpha/β, useful in metastatic breast cancer research. |
| Targets&IC50 | FGFR2:82.5 nM, FGFR1:17.5 nM, VEGFR1:7 nM, VEGFR2:25 nM, VEGFR3:10 nM |
| In vitro | Lucitanib dihydrochloride (E-3810 dihydrochloride) has potent inhibitory effects on VEGFR and FGFR autophosphorylation and can effectively inhibit VEGF- and bFGF-induced HUVEC proliferation with IC50 values of 40 and 50 nM, respectively. It can also inhibit CSF-1R with an IC50 value of 5 nM. [1] |
| In vivo | Lucitanib dihydrochloride (E-3810 dihydrochloride) (20 mg/kg, oral, 7 days) treated mice, Lucitanib completely inhibited the bFGF-induced angiogenic response. Methods: Lucitanib dihydrochloride (15 mg/kg, oral, 30 days) was treated in mice bearing the MDA-MB-231 advanced breast cancer model, and tumor size was evaluated in vivo. Results: Lucitanib dihydrochloride effectively stabilized tumor growth. [3] |
| Alias | E-3810 dihydrochloride, E3810 dihydrochloride, CO-3810 dihydrochloride, CO3810 dihydrochloride, AL3810 dihydrochloride, AL 3810 dihydrochloride |
| Molecular Weight | 516.42 |
| Formula | C26H27Cl2N3O4 |
| Cas No. | 2108875-91-6 |
| Smiles | O=C(C1=CC=CC2=CC(OC3=C4C=C(OC)C(OCC5(CC5)N)=CC4=NC=C3)=CC=C21)NC.Cl.Cl |
Storage & Solubility Information
| Storage | store at -20°C | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 16 mg/mL (30.98 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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