Shopping Cart

Remove All
Your shopping cart is currently empty

MAT2A inhibitor 6

Name: MAT2A inhibitor 6
Brand: TargetMol
SKU: T89595
Rating: 4.5 (1 reviews)

😃Good

Catalog No. T89595Cas No. 2447686-21-5

MAT2A inhibitor 6 (Compound 3N-h) is a compound renowned for its specificity, oral activity, and yellow fluorescence as a MAT2A inhibitor (IC50=26 nM). It enables visualization of MAT2A both in vitro and in vivo (λex=430 nm, λem= 585 nm). Additionally, MAT2A inhibitor 6 induces apoptosis and possesses anticancer properties, making it useful for cancer research.

MAT2A inhibitor 6

😃Good

Catalog No. T89595Cas No. 2447686-21-5

Pack Size	Price	Availability	Quantity
10 mg	Inquiry	10-14 weeks
50 mg	Inquiry	10-14 weeks

Bulk & Custom

Add to Cart

Questions

Resource Download

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	MAT2A inhibitor 6 (Compound 3N-h) is a compound renowned for its specificity, oral activity, and yellow fluorescence as a MAT2A inhibitor (IC50=26 nM). It enables visualization of MAT2A both in vitro and in vivo (λex=430 nm, λem= 585 nm). Additionally, MAT2A inhibitor 6 induces apoptosis and possesses anticancer properties, making it useful for cancer research.
In vitro	MAT2A inhibitor 6 (Compound 3N-h) significantly suppresses the proliferation of HCT-116 (MTAP KO) cells with an IC50 value of 0.1 μM over 72 hours. At a concentration of 1 μM and a duration of 24 hours, it also induces cell apoptosis (43% of cells in early or late-stage apoptosis) but is virtually non-toxic to wild-type HCT-116 cells.
In vivo	MAT2A inhibitor 6 (Compound 3N-h) (50 mg/kg; ) demonstrated antitumor activity by inhibiting the growth of HCT-116 (MTAP KO) tumors in Balb/c mice carrying the HCT-116 (MTAP KO) tumor.

Chemical Properties

Molecular Weight	463.44
Formula	C₂₄H₁₉F₂N₅O₃
Cas No.	2447686-21-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc