Shopping Cart
- Remove All
Your shopping cart is currently empty
MDX-1342
😃Good
Catalog No. T81829Cas No. 1646327-65-2
MDX-1342, a fully human monoclonal antibody (HuMAb), targets the CD19 membrane receptor with high specificity and affinity. It exhibits antibody-dependent cellular cytotoxicity (ADCC) and is utilized in researching B-lymphocyte malignancies and autoimmune diseases [1].
MDX-1342
MDX-1342
😃Good
Catalog No. T81829Cas No. 1646327-65-2
MDX-1342, a fully human monoclonal antibody (HuMAb), targets the CD19 membrane receptor with high specificity and affinity. It exhibits antibody-dependent cellular cytotoxicity (ADCC) and is utilized in researching B-lymphocyte malignancies and autoimmune diseases [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | Inquiry | Backorder | |
| 5 mg | Inquiry | Backorder |
Bulk & Custom
Add to Cart
Questions
View MoreContact us for more batch information
Resource Download
Product Introduction
Bioactivity
Chemical Properties
| Description | MDX-1342, a fully human monoclonal antibody (HuMAb), targets the CD19 membrane receptor with high specificity and affinity. It exhibits antibody-dependent cellular cytotoxicity (ADCC) and is utilized in researching B-lymphocyte malignancies and autoimmune diseases [1]. |
| In vitro | MDX-1342 (0-100 μg/mL; 30 min) binds to Ramos, Raji, and ARH-77 cells, demonstrating EC50 values of 0. |
| In vivo | MDX-1342 administered intravenously at doses of 0.03, 0.3, 3, and 30 mg/kg in a 200 μL volume enhances survival in a dose-dependent manner in a mouse B-cell lymphoma model [1]. At single doses of 0.1 or 1 mg/kg, MDX-1342 exhibits low nanomolar affinity for CD19 in cynomolgus monkeys, increased binding to cynomolgus monkey FcγRIIIa, and demonstrates effective B-cell depletion in vivo [1]. |
| Cas No. | 1646327-65-2 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy MDX-1342 | purchase MDX-1342 | MDX-1342 cost | order MDX-1342 | MDX-1342 in vivo | MDX-1342 in vitro
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.