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N,N'-Dimethylhydrazine dihydrochloride

Catalog No. T86949Cas No. 306-37-6
Alias 1,2-Dimethylhydrazine dihydrochloride

'N,N'-Dimethylhydrazine (1,2-Dimethylhydrazine) dihydrochloride functions as a tumor inducer, specifically inducing colon tumors in rodents, as evidenced by references [1] [2].

N,N'-Dimethylhydrazine dihydrochloride

N,N'-Dimethylhydrazine dihydrochloride

Catalog No. T86949Alias 1,2-Dimethylhydrazine dihydrochlorideCas No. 306-37-6
'N,N'-Dimethylhydrazine (1,2-Dimethylhydrazine) dihydrochloride functions as a tumor inducer, specifically inducing colon tumors in rodents, as evidenced by references [1] [2].
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50 mgInquiry10-14 weeks
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Product Introduction

Bioactivity
Description
'N,N'-Dimethylhydrazine (1,2-Dimethylhydrazine) dihydrochloride functions as a tumor inducer, specifically inducing colon tumors in rodents, as evidenced by references [1] [2].
In vivo
N,N'-Dimethylhydrazine (DMH) administered subcutaneously at 20 mg/kg weekly for 24 weeks induces colon cancer in ICR mice. Similarly, in male inbred F344 rats, a dosage of 20 mg in 4 mg/mL normal saline with 1.5% EDTA (pH 6.4) given subcutaneously for 20 or 35 weeks leads to a higher incidence of intestinal adenocarcinomas, particularly in rats fed a meat-based "Western" diet rather than a grain-based diet, with colon cancer occurrence rates of 83% and 31%, respectively [1][2]. In rats, this tumor-inducing effect is effectively inhibited by Lactobacillus acidophilus.
Alias1,2-Dimethylhydrazine dihydrochloride
Chemical Properties
Molecular Weight133.02
FormulaC2H10Cl2N2
Cas No.306-37-6
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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