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Nav1.8-IN-7 (Example 116) serves as a selective inhibitor of Nav1.8, demonstrating more than 50% inhibition at 100 nM specifically for Nav1.8. It exhibits an IC50 of 15.6 μM for the hERG channel. This compound holds promise in the field of pain research [1].
Pack Size | Price | Availability | Quantity |
---|---|---|---|
10 mg | Inquiry | 10-14 weeks | |
50 mg | Inquiry | 10-14 weeks |
Description | Nav1.8-IN-7 (Example 116) serves as a selective inhibitor of Nav1.8, demonstrating more than 50% inhibition at 100 nM specifically for Nav1.8. It exhibits an IC50 of 15.6 μM for the hERG channel. This compound holds promise in the field of pain research [1]. |
In vitro | Nav1.8-IN-9 (Example 116; 1 μM) exhibits inhibition rates of Nav1.1, Nav1.3, Nav1.4, Nav1.5, Nav1.6, and Nav1.7 of 1.2%, 3.7%, <1%, <1%, 2.6%, and <1%, respectively [1]. |
In vivo | Pharmacokinetic Parameters of Nav1.8-IN-7 in male Sprague-Dawley rats [1]: PO (100 mg/kg), C_max (ng/mL) 2566, AUC_0-24 (ng/mL∗h) 42454, t_1/2 (h) 8.7." |
Molecular Weight | 515.84 |
Formula | C22H18ClF4N3O5 |
Cas No. | 2761181-58-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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