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Neuraminidase-IN-18

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Catalog No. T86997Cas No. 2935407-32-0

Neuraminidase-IN-18 (compound N5), a novel polyheterocyclic neuraminidase (NA) inhibitor, demonstrates significant inhibitory activity against H5N1 NA, with an IC 50 of 0.14 μM against the wild-type H5N1 NA and 0.27 μM against the H5N1-H274Y mutant NA. This compound effectively binds to NAs, inhibiting influenza virus replication at the cellular level [1].

Neuraminidase-IN-18

Neuraminidase-IN-18

😃Good
Catalog No. T86997Cas No. 2935407-32-0
Neuraminidase-IN-18 (compound N5), a novel polyheterocyclic neuraminidase (NA) inhibitor, demonstrates significant inhibitory activity against H5N1 NA, with an IC 50 of 0.14 μM against the wild-type H5N1 NA and 0.27 μM against the H5N1-H274Y mutant NA. This compound effectively binds to NAs, inhibiting influenza virus replication at the cellular level [1].
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Product Introduction

Bioactivity
Description
Neuraminidase-IN-18 (compound N5), a novel polyheterocyclic neuraminidase (NA) inhibitor, demonstrates significant inhibitory activity against H5N1 NA, with an IC 50 of 0.14 μM against the wild-type H5N1 NA and 0.27 μM against the H5N1-H274Y mutant NA. This compound effectively binds to NAs, inhibiting influenza virus replication at the cellular level [1].
In vitro
Neuraminidase-IN-18 (compound N5) demonstrates in vitro antiviral activity against H5N1, with an EC50 value of 3.70 μM, as shown by the CCK-8 method [1]. The aromatic fused ring and 1,3,4-oxadiazole ring in Neuraminidase-IN-18 are well-integrated into the active site, facilitating strong hydrogen bonding interactions with three positively charged key arginine residues (Arg118, Arg292, and Arg371) [1].
Chemical Properties
Molecular Weight423.46
FormulaC22H18FN3O3S
Cas No.2935407-32-0
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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