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NR-11c is a selective and potent p38α PROTAC degrader. It effectively degrades p38α in various tumor cells. When administered to mice via intraperitoneal or tail vein injection, NR-11c primarily acts in the liver. It is used for cancer research.
Pack Size | Price | Availability | Quantity |
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10 mg | Inquiry | Backorder | |
50 mg | Inquiry | Backorder |
Description | NR-11c is a selective and potent p38α PROTAC degrader. It effectively degrades p38α in various tumor cells. When administered to mice via intraperitoneal or tail vein injection, NR-11c primarily acts in the liver. It is used for cancer research. |
In vitro | NR-11c (1-1000 nM; 24 hours) effectively degrades p38α in various tumor cell lines, with an observed DC₅₀ of 11.55 nM specifically in MDA-MB-231 cells. |
In vivo | In a mouse model of breast cancer, a single dose of NR-11c (15 mg/kg; intratumoral/peritumoral injection) effectively reduces p38α levels within the tumor. |
Molecular Weight | 1198.22 |
Formula | C59H71BrF2N10O8S |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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