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NUCC-0226272

Name: NUCC-0226272
Brand: TargetMol
SKU: T87044
Rating: 4.5 (1 reviews)

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Catalog No. T87044Cas No. 3004503-12-9

NUCC-0226272, a potent PROTAC, induces the degradation of EZH2 and exhibits anti-proliferative effects. It holds promise for application in cancer research [1].

NUCC-0226272

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Catalog No. T87044Cas No. 3004503-12-9

NUCC-0226272, a potent PROTAC, induces the degradation of EZH2 and exhibits anti-proliferative effects. It holds promise for application in cancer research [1].

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Product Introduction

Bioactivity

Description	NUCC-0226272, a potent PROTAC, induces the degradation of EZH2 and exhibits anti-proliferative effects. It holds promise for application in cancer research [1].
In vitro	NUCC-0226272 exhibits antiproliferative effects on LNCaP and 22Rv1 cells at concentrations of 0.01-10 μM over 5 days. At 10 μM over 6 days, it shows significant degradation of EZH2, reduction of the PRC2 component SUZ12, and decreased levels of H3K27me3 in C4-2B cells [1].
In vivo	Pharmacokinetic parameters of NUCC-0226272 in C57Bl/6 mice [1] are as follows: after an IP dose of 4 mg/kg, T_max is 0.83 hours, C_max reaches 3650 ng/mL, AUC_last is 12777389 min·ng/mL, t_1/2 is 3.46 hours, clearance (CL) is 3.11 mL/min/kg, and volume of steady-state distribution (V_ss) is 3.11 L/kg.

Chemical Properties

Molecular Weight	1182.56
Formula	C₆₇H₉₁N₉O₈S
Cas No.	3004503-12-9

Storage & Solubility Information

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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