Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

Octyl Orlistat

😃Good
Catalog No. T202399Cas No. 1243011-56-4
Alias N-Formyl-L-leucine (1S)-1-[[(2S,3S)-3-octyl-4-oxo-2-oxetanyl]methyl]dodecyl ester, L-Leucine, N-formyl-, (1S)-1-[[(2S,3S)-3-octyl-4-oxo-2-oxetanyl]methyl]dodecyl ester, [(2S)-1-[(2S,3S)-3-octyl-4-oxooxetan-2-yl]tridecan-2-yl](2S)-2-formamido-4-methylpentanoate

Octyl Orlistat, a potential fatty acid synthase (FASN) inhibitor, has demonstrated significant effectiveness in reducing tumor cell proliferation. By targeting FASN and inducing apoptosis, Orlistat is under investigation as an anti-tumor compound. Compared to Cerulenin and C75, Orlistat shows greater inhibitory potency in cell culture and cell lines. In LN229 cells, treatment with 200 µM Orlistat for 48 hours resulted in a 63.9 ± 8.7% reduction in cell growth, while in LT68 cells, the reduction was 76.3 ± 23.7%. Organotypic slice cultures treated with Orlistat exhibited decreased proliferation after Ki67 staining and an increase in caspase-3 cleavage.

Octyl Orlistat

Octyl Orlistat

😃Good
Catalog No. T202399Alias N-Formyl-L-leucine (1S)-1-[[(2S,3S)-3-octyl-4-oxo-2-oxetanyl]methyl]dodecyl ester, L-Leucine, N-formyl-, (1S)-1-[[(2S,3S)-3-octyl-4-oxo-2-oxetanyl]methyl]dodecyl ester, [(2S)-1-[(2S,3S)-3-octyl-4-oxooxetan-2-yl]tridecan-2-yl](2S)-2-formamido-4-methylpentanoateCas No. 1243011-56-4
Octyl Orlistat, a potential fatty acid synthase (FASN) inhibitor, has demonstrated significant effectiveness in reducing tumor cell proliferation. By targeting FASN and inducing apoptosis, Orlistat is under investigation as an anti-tumor compound. Compared to Cerulenin and C75, Orlistat shows greater inhibitory potency in cell culture and cell lines. In LN229 cells, treatment with 200 µM Orlistat for 48 hours resulted in a 63.9 ± 8.7% reduction in cell growth, while in LT68 cells, the reduction was 76.3 ± 23.7%. Organotypic slice cultures treated with Orlistat exhibited decreased proliferation after Ki67 staining and an increase in caspase-3 cleavage.
Pack SizePriceAvailabilityQuantity
10 mgInquiry10-14 weeks
50 mgInquiry10-14 weeks
Bulk & Custom
Add to Cart
Questions
TargetMol
View More
Contact us for more batch information
Resource Download
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity
Description
Octyl Orlistat, a potential fatty acid synthase (FASN) inhibitor, has demonstrated significant effectiveness in reducing tumor cell proliferation. By targeting FASN and inducing apoptosis, Orlistat is under investigation as an anti-tumor compound. Compared to Cerulenin and C75, Orlistat shows greater inhibitory potency in cell culture and cell lines. In LN229 cells, treatment with 200 µM Orlistat for 48 hours resulted in a 63.9 ± 8.7% reduction in cell growth, while in LT68 cells, the reduction was 76.3 ± 23.7%. Organotypic slice cultures treated with Orlistat exhibited decreased proliferation after Ki67 staining and an increase in caspase-3 cleavage.
AliasN-Formyl-L-leucine (1S)-1-[[(2S,3S)-3-octyl-4-oxo-2-oxetanyl]methyl]dodecyl ester, L-Leucine, N-formyl-, (1S)-1-[[(2S,3S)-3-octyl-4-oxo-2-oxetanyl]methyl]dodecyl ester, [(2S)-1-[(2S,3S)-3-octyl-4-oxooxetan-2-yl]tridecan-2-yl](2S)-2-formamido-4-methylpentanoate
Chemical Properties
Molecular Weight523.79
FormulaC31H57NO5
Cas No.1243011-56-4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
%Tween 80
%ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Related Tags: buy Octyl Orlistat | purchase Octyl Orlistat | Octyl Orlistat cost | order Octyl Orlistat | Octyl Orlistat chemical structure | Octyl Orlistat formula | Octyl Orlistat molecular weight