OG-L002 hydrochloride is an effective and highly selective inhibitor of LSD1, with an IC50 of 0.02 µM. Additionally, it serves as an efficient monoamine oxidase (MAO) inhibitor, exhibiting IC50 values of 1.38 µM for MAO-A and 0.72 µM for MAO-B. This compound also effectively suppresses the expression of the HSV1E gene.

OG-L002 effectively suppresses viral immediate-early (IE) gene expression in cells, displaying a significantly lower half-maximal inhibitory concentration (IC 50) compared to the control monoamine oxidase inhibitor TCP. The IC 50 values are approximately 10 μM in HeLa cells and about 3 μM in human foreskin fibroblast (HFF) cells, whereas TCP shows an IC 50 of around 1 mM.

Administered intraperitoneally at doses ranging from 6-40 mg/kg daily for a week, OG-L002 effectively reduces the presence of viral genomes within the ganglia, exhibiting dose-dependent efficacy observed at both 3 and 5 days after infection. OG-L002 acts as a potent, highly selective inhibitor of LSD1, with an IC 50 of 0.02 μM, and demonstrates significant inhibitory effects on monoamine oxidases (MAO), with IC 50 values of 1.38 μM for MAO-A and 0.72 μM for MAO-B, respectively. Additionally, OG-L002 strongly suppresses the expression of HSV IE genes.