P2Y14R antagonist 2

P2Y14R antagonist 2 (compound 39) is an effective and selective orally-active antagonist of P2Y14R with an IC50 of 0.40 nM. It exhibits anti-inflammatory properties and holds potential for use in studying colitis.

Catalog No. T88648Cas No. 2989271-65-8

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P2Y14R antagonist 2

Catalog No. T88648Cas No. 2989271-65-8

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Pack Size	Price	Availability	Quantity
10 mg	Inquiry	10-14 weeks
50 mg	Inquiry	10-14 weeks

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Product Introduction

Bioactivity

Description	P2Y14R antagonist 2 (compound 39) is an effective and selective orally-active antagonist of P2Y14R with an IC50 of 0.40 nM. It exhibits anti-inflammatory properties and holds potential for use in studying colitis.
Targets&IC50	P2Y14 Receptor:0.40 nM
In vivo	The compound P2Y14R antagonist 2, administered rectally at doses of 50 and 100 µM in a volume of 100µL to male C57BL/6 mice (colitis) for 7 days, exhibited anti-inflammatory effects in mice with colitis. This compound reduced symptoms such as DSS-induced body weight loss, loose stools, rectal bleeding, and colon shortening while also decreasing the spleen weight index.

Chemical Properties

Molecular Weight	372.37
Formula	C₁₈H₁₃FN₂O₄S
Cas No.	2989271-65-8

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