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PROTAC SMARCA2/4-degrader-15
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Catalog No. T89573Cas No. 2568276-81-1
PROTAC SMARCA2/4-degrader-15 (Compound I-335) is a PROTAC degrader designed for the catalytic subunits SMARCA2 and SMARCA4 of the SWI/SNF complex. It degrades SMARCA2 in A549 cells with a DC50 of less than 100 nM; similarly, it degrades SMARCA4 in MV411 cells, also with a DC50 of less than 100 nM.
PROTAC SMARCA2/4-degrader-15
😃Good
Catalog No. T89573Cas No. 2568276-81-1
PROTAC SMARCA2/4-degrader-15 (Compound I-335) is a PROTAC degrader designed for the catalytic subunits SMARCA2 and SMARCA4 of the SWI/SNF complex. It degrades SMARCA2 in A549 cells with a DC50 of less than 100 nM; similarly, it degrades SMARCA4 in MV411 cells, also with a DC50 of less than 100 nM.
| Pack Size | Price | Availability | Quantity |
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| 10 mg | Inquiry | Backorder | |
| 50 mg | Inquiry | Backorder |
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Chemical Properties
| Description | PROTAC SMARCA2/4-degrader-15 (Compound I-335) is a PROTAC degrader designed for the catalytic subunits SMARCA2 and SMARCA4 of the SWI/SNF complex. It degrades SMARCA2 in A549 cells with a DC50 of less than 100 nM; similarly, it degrades SMARCA4 in MV411 cells, also with a DC50 of less than 100 nM. |
| Molecular Weight | 922.11 |
| Formula | C50H55N11O5S |
| Cas No. | 2568276-81-1 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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