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SB-1436

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Catalog No. T87366Cas No. 2925298-08-2

SB-1436 is a Cholinesterase (ChE) inhibitor that inhibits acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and recombinant human acetylcholinesterase (rHuAChE) with IC50 values of 0.176, 0.37, and 0.08 μM, respectively. It inhibits AChE and BChE in a non-competitive manner with Ki values of 0.046 and 0.115 μM, respectively. Additionally, SB-1436 significantly prevents the self-aggregation of Aβ and can be used for neurological disease research [1].

SB-1436

SB-1436

😃Good
Catalog No. T87366Cas No. 2925298-08-2
SB-1436 is a Cholinesterase (ChE) inhibitor that inhibits acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and recombinant human acetylcholinesterase (rHuAChE) with IC50 values of 0.176, 0.37, and 0.08 μM, respectively. It inhibits AChE and BChE in a non-competitive manner with Ki values of 0.046 and 0.115 μM, respectively. Additionally, SB-1436 significantly prevents the self-aggregation of Aβ and can be used for neurological disease research [1].
Pack SizePriceAvailabilityQuantity
10 mgInquiry10-14 weeks
50 mgInquiry10-14 weeks
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Product Introduction

Bioactivity
Description
SB-1436 is a Cholinesterase (ChE) inhibitor that inhibits acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and recombinant human acetylcholinesterase (rHuAChE) with IC50 values of 0.176, 0.37, and 0.08 μM, respectively. It inhibits AChE and BChE in a non-competitive manner with Ki values of 0.046 and 0.115 μM, respectively. Additionally, SB-1436 significantly prevents the self-aggregation of Aβ and can be used for neurological disease research [1].
Targets&IC50
eqBCHE:0.115 μM (Ki), eqBCHE:0.37 μM, Ee AChE:0.176 μM, Ee AChE:0.046 μM (Ki)
In vitro
SB-1436 (Compound 7av) at a concentration of 1 μM for 20 minutes inhibits AChE, BChE, and rHuAChE, with IC50 values of 0.176, 0.37, and 0.08 μM, respectively [1]. This compound, administered at concentrations ranging from 0.78 to 100 μM for 48 hours, decreases the viability of J774A.1 cells and primary astrocytes, with a GI50 of approximately 6.25 μM in both cell lines [1].
Chemical Properties
Molecular Weight405.89
FormulaC25H21ClFNO
Cas No.2925298-08-2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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