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Solabafusp alfa

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Catalog No. T9901A-463

Solabafusp alfa is a humanized IgG4κ antibody targeting CD274/TNFRSF9. The corresponding isotype control is HumanIgG4(S228P) kappa, Isotype Control.

Solabafusp alfa

Solabafusp alfa

😃Good
Catalog No. T9901A-463
Solabafusp alfa is a humanized IgG4κ antibody targeting CD274/TNFRSF9. The corresponding isotype control is HumanIgG4(S228P) kappa, Isotype Control.
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Questions
QHow to recommend specific or broad-spectrum inhibitors for a target? What is the difference between specificity and nonspecificity?
AInhibitors can be classified into two types based on specificity: broad-spectrum (pan) and selective inhibitors. Pan inhibitors are inhibitors of a particular target that have inhibitory effects on all subtypes or members of the entire family. Selective inhibitors have particularly high inhibitory rates or specific inhibitory effects on a subtype of a protein kinase or a member of a family of proteins. The evaluation of the inhibitory efficiency of an inhibitor generally relies on the IC50 value, with lower IC50 values indicating higher inhibitory efficiency. We recommend considering the above characteristics comprehensively when selecting inhibitors, and you can also contact our technical team for recommendations on relevant inhibitors.
QWhat’s EC50?
AHalf maximal effective concentratioin(EC50) refers to the concentration of a compound that achieves 50% of the maximum effect(inhibitory/stimulatory effect),after a specified exposure duration.
QWhat’s IC50?
AHalf-maximal inhibitory concentration (IC50) refers to the concentration of the inhibitor which is required to inhibit a given biological or biochemical function by half.
QWhat’s Kd?
ADissociation consent (Kd) reflects the affinity of a compound for its target. In some cases, it can be equivalent to Ki.
QWhat’s Ki?
AInhibitory consent (Ki) reflects the strength of inhibitor binding to the target, corresponding to the concentration of free inhibitor when 50% of the target is bound by the inhibitor.
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Product Introduction

Bioactivity
Description
Solabafusp alfa is a humanized IgG4κ antibody targeting CD274/TNFRSF9. The corresponding isotype control is HumanIgG4(S228P) kappa, Isotype Control.
Chemical Properties
Storage & Solubility Information
Storagestore at -20°C | Shipping with blue ice.

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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