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Sphingolactone-24
Catalog No. T88577Cas No. 881177-99-7
Alias Sph-24
Sphingolactone-24 (50 µM; 30 min+24 h) inhibits p38 MAPK phosphorylation induced by LPS and counters its anti-apoptotic effects.
Sphingolactone-24
Catalog No. T88577Alias Sph-24Cas No. 881177-99-7
Sphingolactone-24 (50 µM; 30 min+24 h) inhibits p38 MAPK phosphorylation induced by LPS and counters its anti-apoptotic effects.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Sphingolactone-24 (50 µM; 30 min+24 h) inhibits p38 MAPK phosphorylation induced by LPS and counters its anti-apoptotic effects. |
| In vitro | Sphingolactone-24 (50 µM; 30 min+24 h) inhibits p38 MAPK phosphorylation induced by LPS and counters its anti-apoptotic effects. |
| In vivo | Sphingolactone-24, administered at a dose of 1 mg/kg intraperitoneally at 3 and 9 hours post LPS exposure, mitigates the severity of LPS-induced acute lung injury (ALI) and enhances survival rates in mice subjected to pulmonary damage due to LPS. In this study, the animal model utilized was C3H/HeN breeder mice, which received LPS at 10 mg/kg via intranasal instillation. The treatment not only improved survival but also significantly reduced the severity of ALI. |
| Alias | Sph-24 |
| Molecular Weight | 323.43 |
| Formula | C18H29NO4 |
| Cas No. | 881177-99-7 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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