Thalidomide-NH-C6-NH2

Thalidomide-NH-C6-NH2 is a synthetic conjugate designed as an E3 ligase ligand-linker, comprising a Thalidomide-based cereblon ligand connected to a specific linker used in PROTAC technology[1].

Catalog No. T18810Cas No. 2093386-50-4

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Thalidomide-NH-C6-NH2

Catalog No. T18810Cas No. 2093386-50-4

Thalidomide-NH-C6-NH2 is a synthetic conjugate designed as an E3 ligase ligand-linker, comprising a Thalidomide-based cereblon ligand connected to a specific linker used in PROTAC technology[1].

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Product Introduction

Bioactivity

Description	Thalidomide-NH-C6-NH2 is a synthetic conjugate designed as an E3 ligase ligand-linker, comprising a Thalidomide-based cereblon ligand connected to a specific linker used in PROTAC technology[1].
In vitro	PROTACs consist of two distinct ligands linked together: one ligand targets an E3 ubiquitin ligase, while the other targets the protein of interest. They utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Chemical Properties

Molecular Weight	372.42
Formula	C₁₉H₂₄N₄O₄
Cas No.	2093386-50-4

Storage & Solubility Information

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

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Keywords

Thalidomide NH C6 NH2Thalidomide-NH-C6-NH2Thalidomide-NH-C-6-NH2ThalidomideNHC6NH2