Tubulin Inhibitor 36 (Compound 10) serves as a potent novel inhibitor of tubulin polymerization, which consequently induces apoptosis in glioblastoma cells, reflected by an IC50 value of 1.5±0.1 μM. Exhibiting significant anti-mitotic activity, this compound demonstrates anti-tumor potential, particularly useful in glioblastoma multiforme (GBM) research [1].

Tubulin inhibitor 36 (Compound 10) exhibits antiproliferative activity against various human tumor cell lines with IC50 values of 0.039, 0.038, 0.022, 0.025, 0.037, 0.040, and 0.059 μM for HeLa, MCF7, U87 MG, T98G, HepG2, HCT8, and HT-29 cells, respectively [1]. Additionally, at 100 nM concentration over 24, 48, and 72 hours, it arrests mitosis and induces apoptosis in HeLa, MCF7, and U87 MG cells [1].