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VL285 Phenol

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Catalog No. T87622Cas No. 1448188-69-9

VL285 Phenol is an analogue of VL285 featuring a Phenol group. As a small molecule VHL ligand, VL285 serves as a degrader in HaloPROTAC3 synthesis, effectively degrading HaloTag7 fusion proteins (IC 50 = 0.34 μM) [1].

VL285 Phenol

VL285 Phenol

😃Good
Catalog No. T87622Cas No. 1448188-69-9
VL285 Phenol is an analogue of VL285 featuring a Phenol group. As a small molecule VHL ligand, VL285 serves as a degrader in HaloPROTAC3 synthesis, effectively degrading HaloTag7 fusion proteins (IC 50 = 0.34 μM) [1].
Pack SizePriceAvailabilityQuantity
10 mgInquiry10-14 weeks
50 mgInquiry10-14 weeks
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Product Introduction

Bioactivity
Description
VL285 Phenol is an analogue of VL285 featuring a Phenol group. As a small molecule VHL ligand, VL285 serves as a degrader in HaloPROTAC3 synthesis, effectively degrading HaloTag7 fusion proteins (IC 50 = 0.34 μM) [1].
In vitro
VL285 (100 μM; 24 hours) reduces the ability of HaloPROTAC3 to induce degradation of GFP-HaloTag7 [1].
Chemical Properties
Molecular Weight548.65
FormulaC29H32N4O5S
Cas No.1448188-69-9
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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