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w-Conotoxin SVIB

Name: w-Conotoxin SVIB
Brand: TargetMol
SKU: T80780
Rating: 4.5 (1 reviews)

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Catalog No. T80780Cas No. 150433-82-2

ω-Conotoxin SVIB, a peptide toxin derived from Conus venoms, exhibits inhibition of the twitch response with an IC50 value of 37 nM and can induce respiratory distress. At high concentrations, it has been shown to be lethal to mice [1] [2].

w-Conotoxin SVIB

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Catalog No. T80780Cas No. 150433-82-2

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Product Introduction

Bioactivity

Description	ω-Conotoxin SVIB, a peptide toxin derived from Conus venoms, exhibits inhibition of the twitch response with an IC50 value of 37 nM and can induce respiratory distress. At high concentrations, it has been shown to be lethal to mice [1] [2].
In vitro	ω-Conotoxin SVIB, when applied at concentrations ranging from 0.1 to 1000 nM for 20 minutes, suppresses the twitch response at a frequency of 0.1 Hz, exhibiting an inhibitory concentration (IC50) of 37 nM [2].
In vivo	w-Conotoxin SVIB, administered subcutaneously at a dose of 20 pmol/g, induces paralysis and mortality in fish. In mice, it provokes respiratory distress at approximately 70 pmol/g and becomes fatal at a dose near 300 pmol/g [1].

Chemical Properties

Molecular Weight	2739.14
Formula	C₁₀₅H₁₇₆N₃₈O₃₆S₆
Cas No.	150433-82-2

Storage & Solubility Information

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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