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WIZ degrader 3
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Catalog No. T89606Cas No. 2839637-72-6
WIZ degrader 3 (Compound 29) is a degrader of the wide-interval zinc finger motif (WIZ) with an AC50 of 6.4 nM. It induces the expression of fetal hemoglobin (HbF) with an EC50 of 45 nM. This compound is useful for the study of blood disorders such as sickle cell disease and β-thalassemia.
WIZ degrader 3
😃Good
Catalog No. T89606Cas No. 2839637-72-6
WIZ degrader 3 (Compound 29) is a degrader of the wide-interval zinc finger motif (WIZ) with an AC50 of 6.4 nM. It induces the expression of fetal hemoglobin (HbF) with an EC50 of 45 nM. This compound is useful for the study of blood disorders such as sickle cell disease and β-thalassemia.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | WIZ degrader 3 (Compound 29) is a degrader of the wide-interval zinc finger motif (WIZ) with an AC50 of 6.4 nM. It induces the expression of fetal hemoglobin (HbF) with an EC50 of 45 nM. This compound is useful for the study of blood disorders such as sickle cell disease and β-thalassemia. |
| In vitro | WIZ degrader 3 enhances the expression of fetal hemoglobin genes (HBG1/2) and induces fetal hemoglobin (HbF) in primary human erythrocytes. |
| Molecular Weight | 357.41 |
| Formula | C18H23N5O3 |
| Cas No. | 2839637-72-6 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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