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Zanolimumab

Zanolimumab
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Zanolimumab

Catalog No. T80744Cas No. 652153-01-0
Zanolimumab (Anti-Human CD4 Recombinant Antibody) is a fully human monoclonal antibody that targets the CD4 molecule and effectively inhibits T-cell receptor (TCR) signal transduction. It is used in the research of rheumatoid arthritis, psoriasis, melanoma, cutaneous, and peripheral T-cell lymphoma [1].
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Product Introduction

Bioactivity
Description
Zanolimumab (Anti-Human CD4 Recombinant Antibody) is a fully human monoclonal antibody that targets the CD4 molecule and effectively inhibits T-cell receptor (TCR) signal transduction. It is used in the research of rheumatoid arthritis, psoriasis, melanoma, cutaneous, and peripheral T-cell lymphoma [1].
In vitro
Zanolimumab, at concentrations of 10 and 100 ng/mL, effectively induces cytotoxicity in CD4+ T cells, demonstrating enhanced activity on the CD45RO+ subset compared to the CD45RA+ subset. Additionally, within a range of 1-10,000 ng/mL, the compound dose-dependently and through its Fc region, decreases CD4 expression on both purified primary CD4+ T cells and SUP-T1 T cells. Furthermore, Zanolimumab potently suppresses T-cell proliferation initiated by T-cell receptor (TCR) stimulation, as observed with both tetanus toxin and anti-CD3 challenges, and inhibits TCR signal transduction within a 0-30 minute timeframe.
AliasAnti-Human CD4 Recombinant Antibody
Chemical Properties
Cas No.652153-01-0
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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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