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3CLpro/3C-like Protease Protein, SARS-CoV-2, Recombinant

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3CLpro/3C-like Protease Protein, SARS-CoV-2, Recombinant

Catalog No. TMPJ-01449

The viral main proteinase (M pro , also called 3CL pro ), which controls the activities of the coronavirus replication complex. It functions as a cysteine protease engaging in the proteolytic cleavage of the viral precursor polyprotein to a series of functional proteins required for coronavirus replication and is considered as an appealing target for designing anti-SARS agents. 3CLpro/3C-like Protease Protein, SARS-CoV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 30 kDa and the accession number is P0DTC1.

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Pack Size	Price	Availability
10 μg	$231	7-10 days
50 μg	$511	7-10 days
500 μg	$3,720	7-10 days
1 mg	$5,590	7-10 days

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Biological Description

Biological Information	Measured by its ability to cleave a fluorogenic peptide substrate, Dabcyl-KTSAVLQSGFRKME-Edans (Synthetic). The specific activity is 136.6pmol/min/μg. (Regularly tested)
Description	The viral main proteinase (M pro , also called 3CL pro ), which controls the activities of the coronavirus replication complex. It functions as a cysteine protease engaging in the proteolytic cleavage of the viral precursor polyprotein to a series of functional proteins required for coronavirus replication and is considered as an appealing target for designing anti-SARS agents. 3CLpro/3C-like Protease Protein, SARS-CoV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 30 kDa and the accession number is P0DTC1.
Species	SARS-CoV-2
Expression System	E. coli
Tag	Tag Free
Accession Number	P0DTC1
Synonyms	M Proteinase,3C-like Proteinase,3CL Proteinase
Amino Acid	Ser3264-Gln3569
Construction	Ser3264-Gln3569
Protein Purity	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Molecular Weight	30 kDa (reducing condition)
Endotoxin	< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation	Supplied as a 0.2 μm filtered solution of 50 mM Tris-HCl, 1 mM EDTA, pH7.3.
Stability & Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
Research Background	The viral main proteinase (M pro , also called 3CL pro ), which controls the activities of the coronavirus replication complex. It functions as a cysteine protease engaging in the proteolytic cleavage of the viral precursor polyprotein to a series of functional proteins required for coronavirus replication and is considered as an appealing target for designing anti-SARS agents.

Dose Conversion

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Tech Support

Please read the User Guide of Recombinant Proteins for more specific information.