Measured by its ability to cleave a fluorogenic peptide substrate McaKPLGLDpaARNH2，The specific activity is >70 pmol/min/μg.

BACE2 Protein, Human, Recombinant (His) is expressed in HEK293 Cells. The accession number is Q9Y5Z0-1.

Human

HEK293 Cells

UNQ418/PRO852,DRAP,CEAP1,CDA13,BAE2,ASP21,ASP1,ALP56,AEPLC

A DNA sequence encoding the Human BACE2 (Q9Y5Z0-1) (Q9Y5Z0-1) was expressed with a polyhistidine tag at the C-terminus.

≥ 95% as determined by SDS-PAGE. ≥ 95% as determined by SEC-HPLC.

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

BACE2, also known as beta secretase 2, belongs to the peptidase A1 family. It is a protease known to be an important enzyme involved in the cellular pathways. BACE2 has been shown to interact with GGA1 and GGA2. It is the major β-secretase in vivo. BACE2 is located on chromosome 21 and may play a role in alzheimer's disease pathogenesis in down syndrome(DS). Overexpression of BACE2 by lentivirus markedly reduced amyloid β protein production in primary neurons. Despite an extra copy of the BACE2 gene in DS and the increase of its transcription, BACE2 protein levels are unchanged.