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BCMA/TNFRSF17 Protein, Rhesus, Recombinant, Biotinylated

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BCMA/TNFRSF17 Protein, Rhesus, Recombinant, Biotinylated

Catalog No. TMPY-05136

BCMA/TNFRSF17 Protein, Rhesus, Recombinant, Biotinylated is expressed in HEK293 mammalian cells. The predicted molecular weight is 34.5 kDa and the accession number is A0A2K5UD97.

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Pack Size	Price	Availability	Quantity
20 μg	$462	7-10 days
100 μg	$1,070	7-10 days

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Biological Description

Biological Information	Immobilized Cynomolgus BAFF/BLyS hFc at 2 μg/mL (100 μL/well) can bind Rhesus BCMA (hFc & AVI Tag), Biotinylated , the EC50 is 15-80 ng/mL.
Description	BCMA/TNFRSF17 Protein, Rhesus, Recombinant, Biotinylated is expressed in HEK293 mammalian cells. The predicted molecular weight is 34.5 kDa and the accession number is A0A2K5UD97.
Species	Rhesus
Expression System	HEK293 Cells
Tag	Tag Free
Accession Number	A0A2K5UD97
Synonyms	tumor necrosis factor receptor superfamily member 17
Construction	The rhesus TNFRSF17 (XP_001106892.1) (Met1-Ala53) was expressed with a c-terminal AVI tagged Fc region of Human IgG1 tag at the C-terminus. The expressed protein was biotinylated in vivo by the Biotin-Protein ligase (BirA enzyme) which is co-expressed.
Protein Purity	> 95 % as determined by SDS-PAGE.
Molecular Weight	34.5 kDa (predicted)
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	Tumor necrosis factor receptor superfamily, member 17 (TNFRSF17), also known as B cell maturation antigen (BCMA) or CD269 antigen, is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13BBAFF), and to lead to NF-kappaB and MAPK8/JNK activation. TNFRSF17/BCMA/CD269 also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. TNFRSF17/BCMA/CD269 is a receptor for TALL-1 and BCMA activates NF-kappaB through a TRAF5-, TRAF6-, NIK-, and IKK-dependent pathway. The identification of TNFRSF17 as a NF-kappaB-activating receptor for TALL-1 suggests molecular targets for drug development against certain immunodeficient or autoimmune diseases. TNFRSF17/BCMA is a target of donor B-cell immunity in patients with myeloma who respond to DLI. Antibody responses to cell-surface BCMA may contribute directly to tumor rejection in vivo.